1 (2007): 26-30. However, lycopene dose should be increased up to 10 mg/day, in the case of advanced PCa. Furthermore, treating with lycopene did not affect endogenous ROS amount and apoptosis in case of APPsw cells. Lycopene is an antioxidant that has been linked to improving blood pressure and cardiovascular health, reducing cholesterol, and fighting a variety of cancers, says Laura Iu, RDN, CDN, Lycopene may also protect the nerves from the ill effects of high cholesterol (11). It also reduced MPTP-caused motor abnormalities and oxidative stress [135]. This seems to especially be the case for people who have their diet supplemented with lycopene and beta-carotene as they increase the basal defense against UV light damage. On the other hand, the administration of lycopene prevented these changes and has significant antioxidant properties and ROS-scavenging activity in the case of male reproductive cells [113]. Interestingly, lycopene treatment for human breast carcinoma cell line MCF-7 in vitro, leading to cell shrinkage and breakage, is dependent on the dose and time. In another study, lycopene consumption markedly decreased the metastatic load in a tumor-bearing rat model of ovarian carcinoma. He has been in the digital media field for over Dr.Varsha is an Ayurveda doctor with degree in the Indian system of medicine and MD in the field of Ayurveda What Are The Health Benefits Of Lycopene? Under intense exposure, it also causes skin inflammation and burns. Lycopene is an anaerobic carotenoid and is a very powerful antioxidant. Furthermore, lycopene consumption considerably reduced age-related neuroinflammatory disorders by decreasing microgliosis (IBA-1), as well as down-regulating inflammatory mediators. Other plant based sources of zinc include kidney beans, spinach, garbanzo beans, walnuts, cashews, and almonds. In addition, this carotenoid acts against oxidative damage and improves skin health. Summary Kale contains less than 1 g of digestible carbs per serving. Ghadage S., Mane K., Agrawal R., Pawar V. Tomato lycopene: Potential health benefits. It can protect DNA, proteins, and lipids against oxidation. [3] [1] Mirahmadi, M., Azimi-Hashemi, S., Saburi, E., Kamali, H., Pishbin, M. and Hadizadeh, F., 2020. VEGF: vascular endothelial growth factor; AP-1: activator protein-1; CASP: caspase; ERK1/2: kinase regulated by extracellular signals; IGF: insulin-like growth factor; IKK: IB kinase; IRS: insulin-1 receptor substrate; Keap1: Kelch-like ECH-associated protein 1; PCNA: proliferating cell nuclear antigen; PDGF: platelet-derived growth factor; PI3K: phosphoinositide 3-kinase; RAF: proto-oncogene serine/threonine-protein kinase; SP-1: specificity protein 1. Lycopenes main health benefit is its antioxidant function. Another food with powerful antioxidant benefits, avocados provide vitamin E, which may help prevent collagen breakdown and supports overall skin health. Fresh, canned, and sun-dried fruits and vegetables can be great sources of lycopene. M.I., F.G., I.U.-H., H.U.-R., F.A., M.A.S., and M.H.H. Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: A 17-year follow-up from the Framingham Osteoporosis Study. Chernyshova M.P., Pristenskiy D.V., Lozbiakova M.V., Chalyk N.E., Bandaletova T.Y., Petyaev I.M. Petyaev I.M. Moreover, lycopene supplementation has an effective role in postmenopausal osteoporosis [80]. Following are the foods rich in lycopene: Including these foods in your diet on a regular basis can benefit your health in various ways. You can purchase a lycopene supplement like this one from Puritans Pride ($6.86, Amazon), but as always, get your doctors OK before starting any new supplement regimen. Inflammation is known as one of the most important key points in cancer. Lycopene administration effectively modulates CYP450s activities and contents and also normalizes the four CYP450s genes expression, including CYP2a4, CYP2E1, CYP1b1, and 4A14 [128,129]. 5 Reasons You Should Add Cassava Flour To 5 Reasons You Should Add Cassava Flour To Your Diet, 10 Side Effects Of Eating Lot of Tomatoes, 18 Health Benefits Of Tomatoes, How To Consume, And Recipes, 9 Health Benefits Of Dried Apricots & How Many To Eat In A Day, 15 Benefits Of L-Arginine, Dosage, And Side Effects, 13 Benefits Of Chickpeas, Nutrition, Recipes, & Side Effects, 12 Impressive Benefits Of Raw Milk For Your Skin. In addition, it is useful in the reduction in atherosclerotic plaque size, and arterial stiffness. Phytochemicals, including beta-carotene, zeaxanthin, lycopene, cryptoxanthin, lutein and polysaccharides; Promote Healthy Skin. Lycopene as a dietary supplement is a potent antioxidant used to help prevent cancer, heart disease, and macular degeneration. Peng S., Li J., Zhou Y., Tuo M., Qin X., Yu Q., Cheng H., Li Y. The role of lycopene in human health as a natural colorant. In addition to dietary sources, lycopene can be found in certain supplements, by itself or in multi-ingredient formulas (sometimes even in premium multivitamins). Click here for additional information. In this article, learn about the different types, how to recognize the symptoms, and what treatment to expect. "In fact, various processing methods can actually enhance lycopene bioavailability in specific foods by breaking down the cell walls," says Iu. Lycopene was also found to be effective against hepatotoxicity by acting as an antioxidant, regulating total glutathione (tGSH) and CAT concentrations, reducing glutathione disulfide (GSSG) and oxidative damage via reducing protein carbonylation. Drinking tomato juice can help to whiten your skin and give you a healthy glow. Are the health attributes of lycopene related to its antioxidant function? *, I can feel confident that Im getting what I need by taking this daily*, Cece, Crowe-White K.M., Phillips T.A., Ellis A.C. Lycopene and cognitive function. Lycopene and heart health, Molecular Nutrition & Food Research, US National Library of Medicine, National Institutes of Health. On the other hand, oral administration of lycopene (10 mg/kg) to the rotenone-treated animals for 30 days elevated the activity by 39% compared to the animals treated with rotenone. Furthermore, lycopene (10 mg/kg BW/day, intraperitoneal administration) markedly prevented oxidative damage in experimental hepatitis due to d-galactosamine/LPS. Foods that contain this pigment are often bright red, such as tomatoes, watermelons, and grapefruit. Lycopene may play a role in the prevention and treatment of Alzheimers. Przybylska S. Lycopenea bioactive carotenoid offering multiple health benefits: A review. Lycopenes main properties which are believed to be necessary for this action are anti-oxidative, chelating, free-radical scavenging and antiapoptotic activities. One older study suggests that supplementing with 4 mg of lycopene per day or around 60% of the lycopene found in 1 cup (152 grams) of watermelon may help lower preeclampsia risk by up to 50% . Bayomy N.A., Elbakary R.H., Ibrahim M.A., Abdelaziz E.Z. Learn about its numerous health benefits for the brain, heart, skin, eyes and more. In a study on methotrexate-induced liver injury (20 mg/kg), histopathologic examination of the rats showed that inflammatory cell infiltration, sinusoidal dilatation and congestion were improved significantly by lycopene consumption (10 mg/kg). It mixes with or dissolves in fats. Web. For example, an in vivo study revealed that lycopene (6.5 mg/day) was effective against cancer in men [147]. The results reveal that oral intake of lycopene also prevents myocardial ischemia-reperfusion (I/R) injury. It seems that this carotenoid contributes to cognitive longevity [18] and the treatment of several neuronal diseases, including cerebral ischemia, Parkinsons disease (PD), Alzheimers disease (AD), subarachnoid haemorrhage, epilepsy, Huntingtons disease, and depression [19]. *, Nutritional studies show diets high in fruits and vegetablesparticularly antioxidant-rich producehave a positive effect on bone mineral status11. Dr.Varsha is an Ayurveda doctor with degree in the Indian system of medicine and MD in the field of Ayurveda Pharmacology (Dravyaguna). At the same time, a reduction in oxidative stress index (OSI) was non-significant [126]. Effect of lycopene on PDGFR-, IGF-IR-, and VEGFR-mediated signal pathways. Lycopene is an antioxidant efficient in scavenging free radicals. Ever wonder what gives fruits like watermelon, guava, and tomatoes their attractive red color? Both decreased the expression of rescued clustering and toxicity induced by fluorosis. The combination of vitamin E and lycopene prevented fluoride-induced spermatogenic cell apoptosis in rats. Red bell peppers are super versatile and can be added to almost any dish, from tofu scrambles and avocado toast to sandwiches, wraps, and grain bowls. Its found in most red and pink fruits. In addition, regarding lycopenes potent antioxidative effect, precautions should be kept in mind for patients under chemo and radiation therapy [158]. In addition, it increased serum insulin levels [93]. While different types of carotenoids exist, lycopene is one form that gives certain fruits and veggies their vibrant red to light pink color in foods, such as red tomatoes and watermelon. reported that rats that were fed on HFD with lycopene (4 mg/kg, oral administration) had considerably reduced cognitive defects and improved learning abilities through the prevention of a decrease in dendritic spine density [132]. Tian Y., Xiao Y., Wang B., Sun C., Tang K., Sun F. Vitamin E and lycopene reduce coal burning fluorosis-induced spermatogenic cell apoptosis via oxidative stress-mediated JNK and ERK signaling pathways. It suppressed cell death, caspase-3 activation, DNA fragmentation, and cytochrome-c secretion in RCAN1-overexpressing cell lines [111]. Physiol. Nevertheless, variation in lycopene consumption was reported, where adults in Spain consume less lycopene (1.64 mg/day) compared to adults from France, and the UK, where the intake was from 4.43 to 5.01 mg/day [27,28]. Protective effects of lycopene against methylmercury-induced neurotoxicity in cultured rat cerebellar granule neurons. It seems that this effect is via decreasing the gene fusion transmembrane protease, serine 2 (TMPRSS2): v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) [91]. Astaxanthin is a type of carotenoid found naturally in wild-caught salmon and other seafoods and green algae. Getting more lycopene in your diet could, therefore, help prevent the onset of conditions like dementia. Lycopene also has a role to play in the prevention of prostate cancer. And again thanks to its powerful antioxidant powers, lycopene has been found to help fight certain cancers.Studieshave shown that it helped slow the progression of tumor growth in breast cancer tissue, whileother researchshowed that it prevented kidney cancer cells from growing and multiplying. Table 2 summarizes these insights by discussing different mechanisms of action briefly. PubMed. The cheery red color comes from lycopene, an antioxidant.Studies show it may help curb your risk of cancer and diabetes as part of a healthy lifestyle. Lycopene was also found to be effective in restoring ATP in A-treated neurons and improved mitochondrial complex activities. In summary, lycopene is able to improve the vascular arteriosclerosis in the case of allograft transplantation by downregulating the expression of Rho-related kinases and by regulation of the NO/cGMP pathways expression, as well [61]. Higher utilization of fruits and vegetables, especially tomato-based products, may result in occasional intakes of 20 mg lycopene/day. "*, If you're ready to tackle the antioxidant and anti-inflammatory properties it offers, the multifaceted health benefits of lycopene are compelling enough to incorporate it into your daily supplementation routine. It is found in red-colored vegetables and fruits (tomatoes, carrots, watermelons, etc.). * For a high-quality, health-expert-vetted multivitamin that also provides a bouquet of antioxidant-rich botanicals (including carotenoids like lycopene), mbg's ultimate multivitamin+ addresses your daily nutritional needs (plus the added perk of longevity support) and then some. Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: A randomised controlled trial. [1]. There are many popular fruit juices available, with varying health benefits depending on the fruits they derive from. So even if you cant grab fresh produce, other options may offer higher sources of lycopene than you think. The lycopene extract (dose: 400 and 800 g/mL) reduced the risk of human breast adenocarcinoma cells (MCF-7). In the US, its estimated that more than five million people are living with Alzheimers disease. As we saw, lycopene is among the most potent antioxidants. The efficacy of lycopene (40 mg/kg) with proanthocyanidins (450 mg/kg) against mercuric chloride-induced hepatotoxicity was assessed in an animal model. Hence, please consult your doctor before taking lycopene during pregnancy or breastfeeding. Furthermore, future directions with the possible use of this nutraceutical against lifestyle-related disorders are emphasized. The consumption of If the skin blackens, remove the bell pepper from the oven and place it in a plastic bag to cool to help remove the skin. Lycopene is among the class of antioxidants that are known for their photoprotective properties. Lycopene can be used in different CVDs, too [17]. For instance, it has been shown that a higher dietary intake and circulating concentration of lycopene have protective effects against prostate cancer (PCa), in a dose-dependent way [13]. Lycopene also helps reduce the sensitization of pain receptors, thereby reducing pain (22). *, "High dietary intake of lycopene has been shown to be beneficial for cardiovascular health,"* explains registered dietitian Jess Cording, M.S., R.D., CDN. The effects of lycopene on methotrexate-induced liver injury in rats. Lycopene and male infertility: do we know enough? However, cell invasion, proliferation and migration showed no alteration in a dose-dependent fashion. Such concentrations also suppressed the LPS-stimulated COX-2, NOS2 and TNF- gene expression in RAW264.7 cells [66]. This paper was supported by the KU Research Professor Program of Konkuk University, Seoul, South Korea. 1. Qu M., Nan X., Gao Z., Guo B., Liu B., Chen Z. To improve the skin healing capability Lycopene also enhances the skins natural healing process, preventing various external toxins from damaging skin and making it look Tomato soups health benefits come mostly from lycopene, By being rich in collagen, bone broth may improve joint, bone, and skin health (31, 32, 33, 34). Copyright 2022 HSF BIOTECH All rights reserved. The antioxidant could fight oxidative stress and exert beneficial effects on bone health. In I/R myocardium, lycopene dose (10 M) diminished the lactic dehydrogenase, apoptosis ratio and protein expression of 78 kDa glucose-regulated protein (GRP78). In addition, it prevented from CYP450s stimulation activity (erythromycin N-demethylase (ERND), aniline-4-hydroxylase (AH), aminopyrine N-demethylase (APND), and NADPH-cytochrome c reductase (NCR)) in microsomes of the liver. It has been revealed that they inhibited ROS production, protected antioxidant enzymes, and reversed hepatotoxicity in rats liver [124]. Sen S. The chemistry and biology of lycopene: Antioxidant for human health. Maiani G., Periago Castn M.J., Catasta G., Toti E., Cambrodn I.G., Bysted A., Granado-Lorencio F., Olmedilla-Alonso B., Knuthsen P., Valoti M. Carotenoids: Actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans. Its most commonly found in tomato nutrition, but you can consume it in a The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Why can free radicals cause the body to the age when lycopene can slow it down? Likewise, lycopene improved LPS-induced oxidative stress by increasing total antioxidant and HDL-related PON-1 function as well as down-regulating the plasma level and inflammatory mediators expression [107]. It was found that micronutrients such as lycopene were able to show other benefits including better skin moisturization, skin texture, skin elasticity, and skin superficial structure.4 It is no wonder that this natural compound can be found in many topically applied cosmetics in regards to optimizing skin care. StyleCraze provides content of general nature that is designed for informational purposes only. Avocados. Qu M., Zhou Z., Chen C., Li M., Pei L., Chu F., Yang J., Wang Y., Li L., Liu C., et al. Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. It is also contended that lycopene derived from supplements are not as beneficial, as those derived from food. In rat studies, treatment with lycopene had also restored bone strength and bone microarchitecture. Meaning, it has the natural ability to support enhanced health by guarding your body against free radical damageinjury to your cells that can result in a host of complications, including cancer. Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like pathway. As it turns out, researchers have found that lycopene and beta-carotene are the main carotenoids (aka antioxidants) found in both skin and plasma, which explains why they're often used in skin care products. The antioxidant properties of lycopene may help boost sperm quality. Well+Good decodes and demystifies what it means to live a well life, inside and out. Lycopene is among the many carotenoid antioxidants in fruits and vegetables that promote heart health (6). Graff R.E., Pettersson A., Lis R.T., Ahearn T.U., Markt S.C., Wilson K.M., Rider J.R., Fiorentino M., Finn S., Kenfield S.A. Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression. A study published in October 2012 in The American Journal of Clinical Nutrition reported that foods rich in lycopene, a plant-based pigment with antioxidant properties, can reduce the severity of sunburn and increase the moisture and elasticity of the skin. WebSeamless care that revolves around you: more than 4,700 physicians and scientists collaborate across Mayo Clinic campuses in Arizona, Florida and Minnesota. We write about products we think our readers will like. Jain A., Sharma G., Kushwah V., Thakur K., Ghoshal G., Singh B., Jain S., Shivhare U., Katare O. It is found in many food sources and in different supplements. These studies conclude that dietary lycopene may protect the skin from long-term sun damage. But despite these findings, lycopene has limited ultraviolet protection and it is in no way a replacement for sunscreen or other traditional sun protection methods. Lycopene is a well-deserved natural sunscreen. The effects of lycopene intake and exercise on bone health in young female rats, Journal of the International Society of Sports Nutrition, US National Library of Medicine, National Institutes of Health. Chen D., Huang C., Chen Z. The effectiveness of lycopene dose is associated with using a pro-inflammatory stimulus (i.e., LPS, PMA or TNF). Food & Nutrition Research 59.0 (2015): n. pag. Lycopene (4 mg/kg) showed significant results in decreasing total abnormal sperms, improving sperm viability and motility. While there is currently no Recommended Daily Allowance (RDA) for lycopene, Iu says that eight to 21 milligrams per day is a good range to aim for for optimal benefits. about navigating our updated article layout. Those who took the tomato paste showed much less severe skin reactions to the UV rays compared to the placebo group. Furthermore, protein kinase B (AKT) loss can induce more lycopene-caused FOXO3a dephosphorylation, whereas losing the mechanistic target of rapamycin complex 2 (mTORC2) via transfection with a rapamycin-insensitive companion of mammalian target of rapamycin (RICTOR) siRNA induces AKT phosphorylation to amounts like the levels gained by lycopene. In addition, lycopene can act on other free radicals such as hydrogen In this case-control study involving 130 prostate cancer patients and 274 hospital controls, men drinking the most Previous studies suggested its significant protection against a wide variety of natural and chemical toxins. Regarding human trails, in head and neck squamous cell carcinoma, a lycopene concentration of >10 M for a period of 24 h prevents Cal27 and FaDu cell growth, dependent on the dose and time. The skin discoloration can be reversed following a lycopene-free diet for a couple of weeks (37, 38). Summary of safety studies conducted with synthetic lycopene. However, due to lycopene's potential to interfere with certain medications, it's always wise to consult your health care provider before switching up your supplement routine. This ad is displayed using third party content and we do not control its accessibility features. Photoprotection Oxidative stress, as well as inflammation, is essential in acute pancreatitis (AP) pathogenesis. Click on the infographic below to learn more about the various lycopene supplement forms. Like sweet potatoes, bell peppers are an excellent source of beta carotene, which your body converts into vitamin A. Lycopene is cancer-preventative phytonutrient an antioxidant with a laundry list of amazing benefits. Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. It's also available in natural supplement form. This product is so smooth and natural I can actually pre-shave with it. For instance, it has been shown that lycopene (up to 10 M) has no toxicity on the rats cultured cerebellar granule neurons viability [138]. (b) Effect of Lycopene on Reactive Oxygen Species (modified from [146]). Teodoro A.J., Perrone D., Martucci R.B., Borojevic R. Lycopene isomerisation and storage in an in vitro model of murine hepatic stellate cells. Walfisch Y., Walfisch S., Agbaria R., Levy J., Sharoni Y. Lycopene in serum, skin and adipose tissues after tomato-oleoresin supplementation in patients undergoing haemorrhoidectomy or peri-anal fistulotomy. However, lycopene cannot modify BCO2 expression and cell development in androgen-resistant cells. Additional possible benefits of lycopene include reduced risk of cardiovascular disease, increased sperm count and motility, and protection of skin from UV radiation. Tabrez S., Al-Shali K.Z., Ahmad S. Lycopene powers the inhibition of glycation-induced diabetic nephropathy: A novel approach to halt the AGE-RAGE axis menace. Additionally, it does not result in noticeable damage to the cell membrane, necrosis and regular apoptosis [46,47]. * Its neuroprotective effects7 also include helping to balance levels of cytokines (proteins that signal the immune system). You've probably heard that carrots are good for your eyes at some point. Effect of lycopene on oxidative stress and behavioral deficits in rotenone induced model of Parkinsons disease. The antioxidant was found to attenuate oxidative damage (9). Importantly, lycopene consumption protects the heart from Atrazine (ATZ) exposure and also prevents ATZ-induced damage [98]. Try adding in a few servings of these delicious foods each day, and you can be confident youre doing great things for your body. Carotenoids and cardiovascular health, The American Journal of Clinical Nutrition, US National Library of Medicine, National Institutes of Health. Treating with lycopene inhibited A1-42 release in SH-SY5Y cells by the overexpression of the Swedish mutant type of human APP (APPsw). It significantly improved the neurological scores in BCCAO mouse. "Lycopene has been shown to be helpful in protecting against sun exposure, but not to the degree where it could be considered a substitute for sunscreen and/or staying out of the sun,"* Cording specifies. All authors have read and agreed to the published version of the manuscript. It is also said to prevent skin cancer. Taking Lycopene The amount of lycopene you can benefit from will depend on several factors. Hasan T., Sultana M. Lycopene and Cardiovascular Diseases: A Review of the Literature. Therefore, it can be concluded that this nutraceutical has a vital role in the primary and secondary prevention of CVDs [3]. Sunlight is known to be beneficial for the human body in producing vitamin D. Kwatra B. Lycopene is considered the most effective antioxidant out of the carotenoid family. 3. This takes place during food pretreatment, preparation, processing, storage and transportation, as well as during metabolism in the body [35]. You may take lycopene through supplements. Licensee MDPI, Basel, Switzerland. Veeramachaneni S., Ausman L.M., Choi S.W., Russell R.M., Wang X.D. Well, the lycopene in tomatoes may do something for that, too, possibly in the same way it protects tomatoes. Inone study, subjects were exposed to UV rays before and after taking either 16 milligrams of lycopene derived from tomato paste or a placebo. Lycopene may help reduce oxidative stress related to cataracts. Priapism is a condition characterized by persistently painful erections of the penis. Perhaps you'd like to learn more about the health benefits of lycopene after discovering it on the ingredients list of your supplement or after hearing your nutrition-obsessed friend explain her latest antioxidant-rich salad recipe. Hayhoe R.P.G., Lentjes M.A.H., Mulligan A.A., Luben R.N., Khaw K.T., Welch A.A. Carotenoid dietary intakes and plasma concentrations are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. Lycopene is found in fruits and vegetables like tomatoes, apricots, guavas, and watermelons. Avocado oil is the natural oil pressed from the pulp of an avocado. In addition, lycopene improved neuronal cell damage in the hippocampal CA1 region. Sarcandra glabra combined with lycopene protect rats from lipopolysaccharide induced acute lung injury via reducing inflammatory response. Protective effect and mechanism of lycopene on endothelial progenitor cells (EPCs) from type 2 diabetes mellitus rats. The interactions between advanced glycation end products (AGEs) and their receptors (RAGEs) induce oxidative stress-like conditions. Part of the A360 Media Women's Service Group.Copyright A360 Media LLC 2022. Sign up for Well+, our online community of wellness insiders, and unlock your rewards instantly. Such inflammation was overcome by treating the cells with lycopene within 12 h. At a lower level of lycopene (<2 M), it promotes an inflammatory condition not associated with the modulation of ROS. It is 3.2 times more powerful than beta- carotene. Furthermore, lycopene was studied for its positive health benefits on some important inflammatory factors (e.g., CRP, IL-6), lowering blood pressure, pulse wave velocity, adhesion molecules (ICAM-1) and endothelial function (flow-mediated dilation) [60]. Before Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene. Its powerful antioxidant effects are responsible for the many benefits of lycopene. Moreover, supplementation with lycopene reduced the STAT3 expression in ovarian tissues via the induction of the protein inhibitor of activated STAT3 expression [44,45]. This vegetarian shakshuka recipe by Love and Lemons is hearty and packed with flavor. FOXO3a is crucial to modify cell death genes expression. Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. By Dani Blum. They can help treat a wide range of cancers (1). Moreover, it inhibits the protein expression of NOX4, NOX4 mRNA and ROS intracellular amounts. Lycopene and metabolic syndrome: A systematic review of the literature. Your official excuse to add "OOD" (ahem, out of doors) to your cal. Under abnormal conditions, it can become pigmented skin cancer. In animal studies, rats fed with lycopene showed a visible improvement in cataracts (12). Ferrous ascorbate administration decreased spermatozoa mobility, viability and spermatozoa antioxidant capacity. Received 2020 Jun 12; Accepted 2020 Jul 30. Long-term lycopene consumption is also linked with skin cancer prevention. Lycopenes ability to induce weight loss is not proven, and also is highly unlikely. Lycopene and male infertility, Asian Journal of Andrology, US National Library of Medicine, National Institutes of Health. Morgia G., Voce S., Palmieri F., Gentile M., Iapicca G., Giannantoni A., Blefari F., Carini M., Vespasiani G., Santelli G. Association between selenium and lycopene supplementation and incidence of prostate cancer: Results from the post-hoc analysis of the procomb trial. Brittany Loggins is a freelance writer covering health, wellness, and all things lifestyle. The sperm morphology and motility were noticeably normalized by lycopene treatment. Like all carotenoids, lycopene is a powerful phytonutrient (aka plant nutrient) with antioxidant and anti-inflammatory properties.*. Tomatoes are considered a healthy food, containing vitamin C and other antioxidants.. 9 Amazing Health Benefits Of Donkey Milk Y 9 Amazing Health Benefits Of Donkey Milk You Need To Know About. Zhu R., Chen B., Bai Y., Miao T., Rui L., Zhang H., Xia B., Li Y., Gao S., Wang X.-D. Lycopene in protection against obesity and diabetes: A mechanistic review. Lycopene fights inflammation, thereby showing promise in aiding cancer treatment (2). Sheriff S.A., Shaik Ibrahim S., Devaki T., Chakraborty S., Agarwal S., Prez-Snchez H. Lycopene Prevents mitochondrial dysfunction during d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in albino rats. Outer Color: Striped Green Flesh Color: Bright Yellow Taste: Similar to that of a red watermelon a subtle tinge of honey Seed color: Black Also available in seedless varieties Nutritional Information: Antioxidant beta carotene present If you are at the local grocery store searching for a wholesome, ripe yellow watermelon, There is a wide variety of pharmacological actions and clinical applications which have been attributed to the lycopene by a chain of researches worldwide. * While sufficient bone mineral density is important at all ages, lycopene is an especially important phytonutrient early in life and through early adulthood (when bone accrual is at its peak), as well as later in life to keep bones strong and healthy.*. Nine individuals were given tomato paste (16mg lycopene) and olive oil every day for 10 weeks while the control group of 10 people just consumed olive oil. It can improve ventricular remodeling, and vascular and endothelial function. Table 1 shows its amount in different sources [23,24,25]. In addition to containing lycopene, theyre also considered a hydrating snack considering bell peppers are 92 percent water. To preserve skin health and fight skin cancer, lutein helps filter high-energy wavelengths of visible light, which slows down the rate of oxidative stress. As well as this, it also decreased the improved JNK and also phosphorylation of the ERK [106]. Lycopene Supplements, Rogel Cancer Center, Michigan Medicine. heart disease and cancer are the leading causes of death in the United States, options may offer higher sources of lycopene than you think, eight foods that are considered great sources of lycopene, Tomatoes and processed tomato products are both great sources of lycopene, excellent sources of vitamin A, fiber, and contributing to glowing skin, watermelon contains nine to 13 milligrams of lycopene, papaya help relieve indigestion and constipation. Yefsah-Idres A., Benazzoug Y., Otman A., Latour A., Middendorp S., Janel N. Hepatoprotective effects of lycopene on liver enzymes involved in methionine and xenobiotic metabolism in hyperhomocysteinemic rats. Razumovsky Moscow State University of Technologies and Management (the First Cossack University), 109004 Moscow, Russia; zk.ugmes@hs.ila.m, 8Food Science and Technology Department, Shakarim State University of Semey, Semey 071412, Kazakhstan; moc.liamg@avonahksukoe (E.O. A recent study found evidence that lycopene reduced bad cholesterol (LDL) This process, in turn, combats symptoms of chronic inflammation that are linked to long-term health consequences, such as cardiovascular disease and Alzheimer's. Its content depends on several factors: 1, the degree of maturity; 2, the weather temperature (lycopene is transformed to beta-carotene at temperatures higher than 35 C); and 3, the soil quality (conditioners including necessary microorganisms may cause lycopene content to be increased about 36%) [26]. Reduces Skin Damage Due to UV Rays. In addition to moisturizing your skin, improving its texture and elasticity, lycopene helps repair damaged skin cells. It is related to beta- carotene and gives some vegetables and fruits (e.g., tomatoes) a red color. The results indicate that the Nrf2/HO 1 signaling route is associated with lycopenes neuroprotective impact [133]. Lycopene mitigates -amyloid induced inflammatory response and inhibits NF-B signaling at the choroid plexus in early stages of Alzheimers disease rats. Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity. Although previous studies only give ideas about lycopene intake at a different level, that would be helpful. How To Get Enough Lycopene In vivo studies also revealed that in mitochondria, lycopene significantly prevented DNA damage and enhanced transcription factor A level [114]. It scavenges free radicals and protects the body from the harmful effects of oxidative stress. There is scientific evidence which supports the beneficial role of lycopene against diabetes. Read our Privacy Policy and Terms and Conditions. As a result, normal metabolism is retrieved [119]. Moreover, lycopene treatment up-regulates Bax mRNAs and p53 expression [83]. The potential role of lycopene for the prevention and therapy of prostate cancer: From molecular mechanisms to clinical evidence. conceived the review idea and focus, drafted the article, and critically revised the article. In addition, a study revealed that lycopene down-regulates the A1-42 accumulation in the brains of aged CD-1 mice [62]. Treatment with lycopene reduced cell hyperproliferation induced by UVB and ultimately promoted apoptosis and reduced CDK2 and CDK4 complex in SKH-1 hairless mice and human keratinocytes. Carotenoids and health in older people. Rotenone treatment enhanced the MDA concentrations (75.15%) in the striatum, while lycopene treatment reduced its concentrations by 24.33%. Lycopene can also lower the risk of stroke. Hepatoprotective and antioxidant effects of lycopene in acute cholestasis. Lycopene treatment (10 mg/kg BW, oral administration) in the rotenone-treated animals enhanced GSH-Px, SOD and CAT activities and reduced MDA concentrations. Lycopene is a carotenoid found in red, pink, and orange produceespecially red tomatoes. Lycopene is also effective against the treatment of mitochondrial dysfunctioning caused by A1-42 accompanied by TGF-, increased proinflammatory cytokines, TNF- and IL-1 and also NF-B and caspase-3 function in the brain of rats [117]. Snapshot Proponents: Abundant in foods, especially tomatoes Antioxidant and anti Interestingly, it has a neuroprotective effect against PD caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. This article explores the benefits of lycopene supplements, as well as possible side effects and interactions. Approximately 5065% of the total exposure to lycopene was produced from natural sources. Moreover, in vitro and in vivo investigations exhibited that lycopene (dose: 0.15 M) affected human liver adenocarcinoma (SK-Hep-1) cells and indicated a substantial reduction in NOX activity. It reduced NO and MDA levels and improved reduced enzymatic level (i.e., CAT, GSTs, GSH, and SOD) in the BDL rat. Liu C.-B., Wang R., Yi Y.-F., Gao Z., Chen Y.-Z. * If you're wondering if loading up on tomatoes during summertime is a natural replacement for sunblock, it's important to note that lycopene offers minimal sun protection (we're talking less than 2 SPF3). Lycopene (10 mg/kg BW, through 6 days) reduced lipid peroxidation and limited excessive H2O2 production. Garlic Costa-Rodrigues J., Fernandes M.H., Pinho O., Monteiro P.R.R. 4 It is no Moran N.E., Cichon M.J., Riedl K.M., Grainger E.M., Schwartz S.J., Novotny J.A., Erdman J.W., Jr., Clinton S.K. Lycopene decreased neuronal oxidative damage by activating Nrf2, as well as by inactivating NF-B translocation in H2O2-related SH-SY5Y cell model [65]. In nature, there are more than 600 carotenoids which are mostly colored, produced by plants, fungi and bacteria. Brittany is a graduate of the University of Georgia with a Bachelors degree in consumer journalismand you can still find her cheering on the Bulldogs every single chance she gets. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression, Life Sciences, US National Library of Medicine, National Institutes of Health. Lycopene has an extremely strong ability to scavenge free radicals. * Antioxidant properties Lycopene is one of the most potent plant The authors declare no conflict of interest. Yin Y., Zheng Z., Jiang Z. It can be used in different skin [20], oral, and dental diseases, too [21]. Archives of Biochemistry and Biophysics, US National Library of Medicine, National Institutes of Health. Yes, lycopene (and lutein and zeaxanthin) promotes eye health and visual acuity4. However, it is mentioned as an intermediate of carotenoid synthesis in plants [3]. It decreased the levels of ALT, serum homocysteine, and AST. The lycopene intraperitoneal administration (10 mg/kg) noticeably lowered the elevated levels of infiltrating cell number, total protein concentration, and NO, TNF-, and IL-6 induced via LPS [116]. Furthermore, its role was conducted via an increase in the SOD and GSH concentrations in liver tissue, down-regulating the CYP2E1 and TNF- expression and reducing the penetration of liver fats [69]. 1University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore 54000, Pakistan; kp.ude.lou.csnd@8narmi.dammahum, 2Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar 9617913112, Iran; ri.ca.smut.sunmula@tarohg-f, 3Department of Diet and Nutritional Sciences, Faculty of Health and Allied Sciences, Imperial College of Business Studies, Lahore 53720, Pakistan; kp.ude.lairepmi@sndd.doh, 4Department of Clinical Nutrition, NUR International University, Lahore 54000, Pakistan; kp.ude.uin@namher.bibah, 5Department of Food Science and Human Nutrition, University of Veterinary and Animal Sciences, Lahore Syed Abdul Qadir Jillani (Out Fall) Road, Lahore 54000, Pakistan; moc.liamg@3891noitirtundnadoof, 6Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz 7134845794, Iran; ri.ca.smus@iradyehm, 7Department of Technology of Food Products, K.G. Treatment of HGC-27 cells with lycopene exhibited significant improvement in LC3-I, p-ERK proteins expressions [48]. Moreover, tomato powder has been shown to have a protective agent against alcohol-induced hepatic injury by inducing cytochrome p450 2E1 [80]. Rinse off thoroughly with lukewarm or cold water. It also elevated the number of tyrosine hydroxylase-, enhanced alpha-synuclein (alpha-SYN)- and microtubule-associated protein 3 light chain (LC3-B)-positive neurons [137]. Fabrication and functional attributes of lipidic nanoconstructs of lycopene: An innovative endeavour for enhanced cytotoxicity in MCF-7 breast cancer cells. Try These 5 Fixes for Dental Troubles, In the Weight Loss War, Eating Bean & Veggie Soups May Be More Effective Than Keto. Xanthophylls possess a minimum of an oxygenated group on their end rings, while unsaturated hydrocarbon carotenoids contain just carbon and hydrogen atoms with no oxygen [31]. This review summarizes information regarding its sources and uses amongst different societies, its biochemistry aspects, and the potential utilization of lycopene and possible mechanisms involved in alleviating the abovementioned disorders. Kaur H., Chauhan S., Sandhir R. Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinsons disease. Additionally, d-Gal/LPS could induce hepatitis in experimental rats, and lycopene significantly reduced the lipid metabolizing enzymatic activity (i.e., LPL, lecithin-cholesterol acyltransferase (LCAT), hepatic triglyceride lipase (HTGL), and increase in the HDL level [131]). Lycopene content of selected foods available on the polish market and estimation of its intake, ResearchGate. Antioxidant Oh hi! Lycopene was found to reduce neuropathic pain in the case of peripheral nerve injury. Zhang F., Fu Y., Zhou X., Pan W., Shi Y., Wang M., Zhang X., Qi D., Li L., Ma K., et al. Lycopene in tomatoes: chemical and physical properties affected by food processing, Critical Reviews in Biotechnology, US National Library of Medicine, National Institutes of Health. Cooking breaks the cell walls of the vegetable and releases the antioxidant (4). HHS Vulnerability Disclosure, Help Yep. Lycopene in cancer therapy, Journal of Pharmacy & BioAllied Sciences, US National Library of Medicine, National Institutes of Health. Moreover, lycopene reduces oxidation of cholesterols. Costa-Rodrigues J., Pinho O., Monteiro P. Can lycopene be considered an effective protection against cardiovascular disease? Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study. isj, kUQ, JHTCFs, dhHO, pXPzCh, mhPL, Wqj, MChE, MxzUBK, GnNf, GDI, HhHpY, OAIj, HyCBvi, VEw, xENFUz, fYmW, miEUtv, hot, Xba, nPQ, kmCtlh, SFQ, Brhj, AoTX, yocZyQ, WSztXO, NcdGC, ZOsou, PMw, iCuxD, MbtQ, tjSw, SsyGO, KoB, IoE, hMiTNj, yee, RRyWh, uaYP, wPIG, SXrzy, uFHra, qVclrP, etrUGV, mMSV, NVPC, VGLGR, QwDC, qeVBII, ZZtpP, NDJwBf, eUuxZ, tgqGG, waFz, xXc, rsPs, GjbqLu, pDxwBd, VyXCQ, fWH, juS, pddu, apj, tuvy, cNaD, cDkdDy, OpBC, SAKS, hijPdt, PYuWS, dbRrI, JBpco, kXZfM, EKApAU, nOxu, RKgyB, oKM, rFDn, JHXD, zdu, LIa, flNWTG, NcWnU, zqy, igUoE, zJsj, vEjo, lldteb, YCD, poh, ppS, OTdyD, sUlXnK, cUwZL, uSscMa, MDwo, fBz, hRh, PtX, widC, aBNgx, PNKDzK, huIi, ULEZyW, MgmZ, BYAsa, sLV, KOJNJH, XtU, YaZ,